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RESEARCH PAPERS

An Analysis of Cell Freezing and Dehydration

[+] Author and Article Information
G. R. Ling, C. L. Tien

Department of Mechanical Engineering, University of California, Berkeley, Calif.

J. Heat Transfer 92(3), 393-398 (Aug 01, 1970) (6 pages) doi:10.1115/1.3449674 History: Received March 17, 1970; Online August 11, 2010

Abstract

A quantitative picture of the effect of low-temperature exposure on the survival of living cells is presented through discussion of solutions to a differential equation relating the volume of intracellular water to the temperature, the cooling rate, and various cell parameters. It is found that for a given cell, a single parameter which depends on the cooling rate governs the behavior of the cell when it is exposed to low temperatures. The analysis develops relationships between solutions to the differential equation and the phenomena affecting cell survival, namely, intracellular freezing and cell dehydration. Theoretical predictions are found to agree well with existing experimental observations.

Copyright © 1970 by ASME
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