Research Papers: Bio-Heat and Mass Transfer

The Limiting Radius for Freezing a Tumor During Percutaneous Cryoablation

[+] Author and Article Information
Akira Nakayama, Yusuke Kuwahara

Department of Mechanical Engineering, Shizuoka University, 3-5-1 Johoku, Hamamatsu 432-8561, Japan

Kansei Iwata

 DGS Computer Ltd., 2-7 Minami-Ohsawa, Hachioji 162-0393, Japan

Masafumi Kawamura

School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan

J. Heat Transfer 130(11), 111101 (Aug 28, 2008) (6 pages) doi:10.1115/1.2969759 History: Received July 19, 2007; Revised May 07, 2008; Published August 28, 2008

The freezing front in a tumor during percutaneous cryoablation therapy was traced both analytically and numerically exploiting a bioheat equation. It has been shown that there exists a limiting size of the tumor, which one single cryoprobe can freeze at the maximum. The freezing front moves radially outward from the cryoprobe and reaches the end, where the heat from the surrounding tissue to the frozen tissue balances with the heat being absorbed by the cryoprobe. An excellent agreement between the analytical and numerical results has been achieved for the time required to freeze the tumor using the cryoprobe of a single needle. An analytical expression for estimating the limiting radius has been derived to give useful information for cryotherapy treatment plans.

Copyright © 2008 by American Society of Mechanical Engineers
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Figure 1

Effective specific heat capacity

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Figure 2

Grid nomenclatures

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Figure 3

Numerical model for cryoablation

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Figure 4

Temperature profile around a probe

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Figure 5

Temporal evolution of isotherms

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Figure 6

Time required for freezing the tumor

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Figure 7

Effects of the perfusion rate on the limiting radius



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