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Research Papers

Skin Electroporation With Passive Transdermal Transport Theory: A Review and a Suggestion for Future Numerical Model Development

[+] Author and Article Information
S. M. Becker

 University of Canterbury, Department of Mechanical Engineering, Private Bag 4800, Christchurch 8140, New Zealandsid.becker@canterbury.ac.nz

J. Heat Transfer 133(1), 011011 (Sep 30, 2010) (9 pages) doi:10.1115/1.4002362 History: Received January 31, 2010; Revised March 16, 2010; Published September 30, 2010; Online September 30, 2010

Skin electroporation is an approach used to enhance the transdermal transport of large molecules in which the skin is exposed to a series of electric pulses, resulting in the structural alteration of the stratum corneum. This article suggests the use of passive transdermal transport models in combination with models depicting the electrically induced structural alterations in order to advance the modeling development of transport associated with skin electroporation. A review of the major physical phenomena observed in skin electroporation transport experiments is provided. A compendium of representative models is made available through a review of the current understanding of the two fields: (1) porous media descriptions of nondestructive transdermal transport and (2) modeling electroporation related structural changes within the skin. To show the applicability and potential of merging transdermal transport modeling with skin electroporation modeling, an example model is developed that combines a brick and mortar style skin representation with a thermodynamic based model of skin electroporation.

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Copyright © 2011 by American Society of Mechanical Engineers
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Figures

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Figure 1

((a) and (b)) Electroporation skin fold overview; ((c) and (d)) close-up of thermal transition near a pre-existing appendageal pore

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Figure 2

A representative heat versus temperature curve of SC lipids in thermal phase transition. Latent heat and phase transition temperature range values taken from data provided in Ref. 20.

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Figure 3

SC brick and mortar representations: (a) symmetric and (b) asymmetric

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Figure 4

Dimensionless solute concentration profile comparisons of symmetric (29) and asymmetric (30) brick and mortar models for a 300 V electroporation pulse at 400 ms. Dashed line indicates epidermis-dermis border; dash-dot-dot represents SC boundary.

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Figure 5

A comparison between the dimensionless transient solute concentration transported below the SC surface by a 300 V electroporation pulse for symmetric (29) and asymmetric (30) brick and mortar models

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