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Technology Reviews

Thermal Processing of Tissue Engineering Scaffolds

[+] Author and Article Information
Alisa Morss Clyne

Department of Mechanical Engineering and Mechanics, School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104asm67@drexel.edu

J. Heat Transfer 133(3), 034001 (Nov 16, 2010) (8 pages) doi:10.1115/1.4002464 History: Received August 14, 2009; Revised October 26, 2009; Published November 16, 2010; Online November 16, 2010

Tissue engineering requires complex three-dimensional scaffolds that mimic natural extracellular matrix function. A wide variety of techniques have been developed to create both fibrous and porous scaffolds out of polymers, ceramics, metals, and composite materials. Existing techniques include fiber bonding, electrospinning, emulsion freeze drying, solvent casting/particulate leaching, gas foaming/particulate leaching, high pressure processing, and thermally induced phase separation. Critical scaffold properties, including pore size, porosity, pore interconnectivity, and mechanical integrity, are determined by thermal processing parameters in many of these techniques. In this review, each tissue engineering scaffold preparation method is discussed, including recent advancements as well as advantages and disadvantages of the technique, with a particular emphasis placed on thermal parameters. Improvements on these existing techniques, as well as new thermal processing methods for tissue engineering scaffolds, will be needed to provide tissue engineers with finer control over tissue and organ development.

Copyright © 2011 by American Society of Mechanical Engineers
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