The complex structures in the film cooling flow field of gas turbines lead to the anisotropic property of the turbulent eddy viscosity and scalar diffusivity. An algebraic anisotropic turbulence model is developed aiming at a more accurate modeling of the Reynolds stress and turbulent scalar flux. In this study, the algebraic anisotropic model is validated by a series of in-house experiments for cylindrical film cooling with compound angle injection of 0, 45, and 90 deg. Adiabatic film cooling effectiveness and flow field are measured using pressure sensitive paint and particle image velocimetry techniques on film cooling test rig in Tsinghua University. Detailed analyses of computational simulations are performed. The algebraic anisotropic model gives a good prediction of the secondary vortices associated with the jet and the trajectory of the jet, therefore improves the prediction of the scalar field. On one hand, the anisotropic eddy viscosity improves the modeling of Reynolds stress and the predictive flow field. On the other hand, the anisotropic turbulent scalar-flux model includes the role of anisotropic eddy viscosity in modeling of scalar flux and directly improves the turbulent scalar flux prediction.