Present study focuses on numerical investigation of fully developed flow and heat transfer through three channels having sine-shaped, triangle-shaped, and arc-shaped wall profiles. All computations are performed at Reynolds number of 600. Finite volume method on collocated grid is used to solve the time-dependent Navier–Stokes and energy equations in primitive variable form. For all the geometries considered in the study, the ratios Hmin/Hmax and L/a are kept fixed to 0.4 and 8.0, respectively. The thermal performances of all the three wall configurations are assessed using integral parameters as well as instantaneous, time-averaged and fluctuating flow fields. The geometry with the sinusoidal-shaped wall profile is found to produce the best thermal properties as compared to the triangle-shaped and the arc-shaped profiles though the obtained heat transfer is the highest for the arc-shaped geometry.