Heat conduction and phase transformations are basic physical-chemical process and control the kinetics of dissociation, fluid flow and strata deformation during hydrate dissociation in sediments. This paper presents a simplified analysis of the thermal process by assuming that the heat-induced evolution can be decoupled from flow and deformation processes. Self-similar solutions for one-, two- and three-phase transformation fronts are obtained. A series of experiments on THF-hydrate-bearing sediments was conducted to test the theory. The theoretical, numerical and experimental results on the evolution of hydrate dissociation front in the sediment are in good agreement.