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Research Papers

Porous Medium Modeling of Combined Effects of Cell Migration and Anisotropicity of Stratum Corneum on Transdermal Drug Delivery

[+] Author and Article Information
Arunn Narasimhan

Professor
Heat Transfer and Thermal Power Laboratory,
Department of Mechanical Engineering,
Indian Institute of Technology Madras,
Chennai 600036, India
e-mail: arunn@iitm.ac.in

Ajith Joseph

Heat Transfer and Thermal Power Laboratory,
Department of Mechanical Engineering,
Indian Institute of Technology Madras,
Chennai 600036, India
e-mail: ajith.jsph@gmail.com

1Corresponding author.

Contributed by the Heat Transfer Division of ASME for publication in the JOURNALOF HEAT TRANSFER. Manuscript received April 30, 2014; final manuscript received March 30, 2015; published online August 11, 2015. Assoc. Editor: Suman Chakraborty.

J. Heat Transfer 137(12), 121007 (Aug 11, 2015) (8 pages) Paper No: HT-14-1277; doi: 10.1115/1.4030923 History: Received April 30, 2014

A numerical model for transdermal drug delivery (TDD) has been developed by treating skin as a composite, dynamic, porous medium. Governing unsteady mass transport equations in porous medium was solved for different cases for up to a period of drug-patch application of 10 hrs. The effects of cell migration and anisotropic diffusive properties of stratum corneum (SC) on TDD are analyzed. Each of the above factors and their combination are found to significantly affect TDD. The cell migration in SC decreases the predicted amount of drug considerably. Their combined effect in TDD helped in identifying four distinct regimes of pharmacological as well as engineering importance within the domain.

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Figures

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Fig. 1

Representative computational domain

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Fig. 2

Computational grid showing (a) entire domain, (b) mesh refinement near to patch, and (c) mesh refinement near to patch edge

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Fig. 3

Comparison of 3D and 2D modeling of TDD; concentration profiles within SC at t = 10,000 s

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Fig. 4

Validation of present model with Alberti et al. [24]; TBF concentration within SC after 2 hrs of application

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Fig. 5

Drug concentration profiles along the depth of skin at center of application of patch for different periods of application when there is no cell migration in SC

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Fig. 6

Comparison of drug concentration profiles along the depth of skin at center of application of patch at steady state with and without cell migration in SC

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Fig. 7

Contours of drug concentration in SC near patch edge without considering cell migration at t = 1000 s

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Fig. 8

Contours of drug concentration in SC near patch edge considering cell migration at t = 1000 s

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Fig. 9

Comparison of effect cell migration rate on amount of drug absorbed

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Fig. 10

Drug concentration in anisotropic SC, near patch edge when there is no cell migration at t = 1000 s

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Fig. 11

Drug concentration in anisotropic SC, near patch edge when there is cell migration at t = 1000 s

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Fig. 12

Combined effect of anisotropy and cell migration at patch edge at mid depth of SC

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