This paper proposes a numerical analysis of entropy generation during mixed convection inside a porous Poiseuille–Benard channel flow, where the Darcy–Brinkman model is used. Irreversibilities due to heat transfer and viscous dissipation have been derived, and then calculated by numerically solving mass, momentum, and energy conservation equations, by using a control volume finite element method (CVFEM). For a fixed value of the thermal Rayleigh (Ra = 104) and the modified Brinkman (Br* = 10−3) numbers, transient entropy generation exhibits a periodic behavior for the medium porosity ε ≥ 0.2, which is described by the onset of thermoconvective cells inside the porous channel. Highest irreversibility is obtained at ε = 0.5. More details about the effects of the Darcy, the Rayleigh, and the modified Brinkman numbers on entropy generation and heat transfer are discussed and graphically presented.