An entropic wall with circulating water inside could be a solution for acclimatizing a new building with high-energy efficiency and high levels of internal comfort. If circulating water is thermally stabilized by exchanging in the ground such has it happens in geothermal plants, a thermal shield could be realized keeping walls in comfort conditions and minimizing energy needs for further temperature regulations. This paper presents optimization guidelines of such a wall with the objective of maximizing the performances of the wall for reaching optimal internal wellness conditions. Optimization has been realized by a constructal law based method, which has been personalized by a step-by-step process and has been named constructal design for efficiency (CDE). The optimization of the system has been produced at different levels. It starts from a preliminary analysis at system levels, which allow defining the best objectives that could be reached. After this preliminary process, the system has been divided into modules, and the critical ones which have higher influence on the performances of the system have been evaluated. This analysis has been coupled also with an industrial analysis with the goal of defining an effective layout, which could be also manufactured with acceptable costs. The result has produced a final solution with a very good compromise between energetic performances and minimization of costs at industrial level. The results open interesting perspectives for the constructal law to become the core of an effective methodology of an industrial design which can couple perfectly with the modular approach which is currently the major part of industrial companies.