An investigation of refrigerant R410A condensation on a shell and tube heat exchanger simulation is conducted. Tests are on the outside of a horizontal smooth tube, a herringbone tube, and a newly developed three-dimensional-enhanced tube, called the enhanced tube (EHT) tube, all of the same outer diameter. Experiments were conducted at a constant saturation temperature of 45 °C, a constant inlet vapor quality of 0.8, a constant outlet vapor quality of 0.1, and mass fluxes ranging from 5 kg/(m2 s) to 50 kg/(m2 s). At low-mass velocities, the smooth tube shows superior performance over the herringbone tube and the EHT tube. The cause might lie in surface tension effects that result in liquid inundation at the lower portion of the tube, thickening the film on the tube and deteriorating the heat transfer performance. Analyses were conducted to find a suitable correlation of the experimental data.