This study investigates the unsteady heat transfer and entropy generation characteristics of a non-Newtonian fluid, squeezed and extruded between two parallel plates. In an effort to capture the underlying thermo-hydrodynamics, the power-law model is used here to describe the constitutive behavior of the non-Newtonian fluid. The results obtained from the present analysis reveal the intricate interplay between the fluid rheology and the squeezing dynamics, toward altering the Nusselt number and Bejan number characteristics. Findings from this study may be utilized to design optimal process parameters for enhanced thermodynamic performance of engineering systems handling complex fluids undergoing simultaneous extrusion and squeezing.