An Analysis of Cell Freezing and Dehydration

[+] Author and Article Information
G. R. Ling, C. L. Tien

Department of Mechanical Engineering, University of California, Berkeley, Calif.

J. Heat Transfer 92(3), 393-398 (Aug 01, 1970) (6 pages) doi:10.1115/1.3449674 History: Received March 17, 1970; Online August 11, 2010


A quantitative picture of the effect of low-temperature exposure on the survival of living cells is presented through discussion of solutions to a differential equation relating the volume of intracellular water to the temperature, the cooling rate, and various cell parameters. It is found that for a given cell, a single parameter which depends on the cooling rate governs the behavior of the cell when it is exposed to low temperatures. The analysis develops relationships between solutions to the differential equation and the phenomena affecting cell survival, namely, intracellular freezing and cell dehydration. Theoretical predictions are found to agree well with existing experimental observations.

Copyright © 1970 by ASME
Your Session has timed out. Please sign back in to continue.





Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In