The long-term goal of our research is to understand the mechanism of osteoarthritis (OA) initiation and progress through experimental and theoretical approaches. In previous theoretical models, joint contact mechanics was implemented without consideration of the fluid boundary conditions and with constant permeability. The primary purpose of this study was to investigate the effect of fluid boundary conditions at the articular surfaces on the contact mechanics, in terms of load sharing and fluid flow properties using variable permeability. The tested conditions included totally sealed surfaces, open surfaces, and open surfaces with variable permeability. While the sealed surface model failed to predict relaxation times and load sharing properly, the class of open surface models (open surfaces with constant permeability, and surfaces with variable permeability) gave good agreement with experiments, in terms of relaxation time and load sharing between the solid and the fluid phase. In particular, the variable permeability model was judged to be the most realistic of the three models, from a biological and physical point of view. This model was then used to simulate joint contact in the early and late stages of OA. In the early stages of OA, the model predicted a decrease in peak contact pressure and an increase in contact area, while in the late stages of OA, peak pressures were increased and contact areas were decreased compared to normal. These findings agree well with experimental observations.
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April 2004
Technical Papers
Effect of Fluid Boundary Conditions on Joint Contact Mechanics and Applications to the Modeling of Osteoarthritic Joints
Salvatore Federico,
Salvatore Federico
Dipartimento di Ingegneria Industriale e Meccanica, Facolta` di Ingegneria, Universita` degli Studi di Catania, Catania, Italy
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Guido La Rosa,
Guido La Rosa
Dipartimento di Ingegneria Industriale e Meccanica, Facolta` di Ingegneria, Universita` degli Studi di Catania, Catania, Italy
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Walter Herzog,
Walter Herzog
Human Performance Laboratory, Faculty of Kinesiology, The University of Calgary, Calgary, Alberta, Canada T2N 1N4
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John Z. Wu
John Z. Wu
Human Performance Laboratory, Faculty of Kinesiology, The University of Calgary, Calgary, Alberta, Canada T2N 1N4
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Salvatore Federico
Dipartimento di Ingegneria Industriale e Meccanica, Facolta` di Ingegneria, Universita` degli Studi di Catania, Catania, Italy
Guido La Rosa
Dipartimento di Ingegneria Industriale e Meccanica, Facolta` di Ingegneria, Universita` degli Studi di Catania, Catania, Italy
Walter Herzog
Human Performance Laboratory, Faculty of Kinesiology, The University of Calgary, Calgary, Alberta, Canada T2N 1N4
John Z. Wu
Human Performance Laboratory, Faculty of Kinesiology, The University of Calgary, Calgary, Alberta, Canada T2N 1N4
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division December 4, 2001; revision received October 1, 2003. Associate Editor: L. A. Setton.
J Biomech Eng. Apr 2004, 126(2): 220-225 (6 pages)
Published Online: May 4, 2004
Article history
Received:
December 4, 2001
Revised:
October 1, 2003
Online:
May 4, 2004
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Citation
Federico , S., La Rosa, G., Herzog, W., and Wu, J. Z. (May 4, 2004). "Effect of Fluid Boundary Conditions on Joint Contact Mechanics and Applications to the Modeling of Osteoarthritic Joints ." ASME. J Biomech Eng. April 2004; 126(2): 220–225. https://doi.org/10.1115/1.1691445
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Erratum: “Effect of Fluid Boundary Conditions on Joint Contact Mechanics and Applications to the Modelling of Osteoarthritic Joints,” J. Biomech. Eng., 126 (2), pp. 220–225
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