While providing nearly trouble-free function for 10–12 years, current bioprosthetic heart valves (BHV) continue to suffer from limited long-term durability. This is usually a result of leaflet calcification and/or structural degeneration, which may be related to regions of stress concentration associated with complex leaflet deformations. In the current work, a dynamic three-dimensional finite element analysis of a pericardial BHV was performed with a recently developed FE implementation of the generalized nonlinear anisotropic Fung-type elastic constitutive model for pericardial BHV tissues (W. Sun and M.S. Sacks, 2005, [Biomech. Model. Mechanobiol., 4(2-3), pp. 190–199]). The pericardial BHV was subjected to time-varying physiological pressure loading to compute the deformation and stress distribution during the opening phase of the valve function. A dynamic sequence of the displacements revealed that the free edge of the leaflet reached the fully open position earlier and the belly region followed. Asymmetry was observed in the resulting displacement and stress distribution due to the fiber direction and the anisotropic characteristics of the Fung-type elastic constitutive material model. The computed stress distribution indicated relatively high magnitudes near the free edge of the leaflet with local bending deformation and subsequently at the leaflet attachment boundary. The maximum computed von Mises stress during the opening phase was . The dynamic analysis indicated that the free edge regions of the leaflets were subjected to significant flexural deformation that may potentially lead to structural degeneration after millions of cycles of valve function. The regions subjected to time varying flexural deformation and high stresses of the present study also correspond to regions of tissue valve calcification and structural failure reported from explanted valves. In addition, the present simulation also demonstrated the importance of including the bending component together with the in-plane material behavior of the leaflets towards physiologically realistic deformation of the leaflets. Dynamic simulations with experimentally determined leaflet material specification can be potentially used to modify the valve towards an optimal design to minimize regions of stress concentration and structural failure.
Skip Nav Destination
e-mail: chandran@engineering.uiowa.edu
Article navigation
October 2006
Technical Papers
Dynamic Simulation Pericardial Bioprosthetic Heart Valve Function
Hyunggun Kim,
Hyunggun Kim
Department of Biomedical Engineering,
University of Iowa
, Iowa City, IA 52242
Search for other works by this author on:
Jia Lu,
Jia Lu
Department of Mechanical and Industrial Engineering,
University of Iowa
, Iowa City, IA 52242
Search for other works by this author on:
Michael S. Sacks,
Michael S. Sacks
Engineered Tissue Mechanics Laboratory, Department of Bioengineering,
University of Pittsburgh
, Pittsburgh, PA
Search for other works by this author on:
Krishnan B. Chandran
Krishnan B. Chandran
Departments of Biomedical and Mechanical and Industrial Engineering,
e-mail: chandran@engineering.uiowa.edu
University of Iowa
, Iowa City, IA IIHR-Hydroscience and Engineering, Iowa City, IA 52242
Search for other works by this author on:
Hyunggun Kim
Department of Biomedical Engineering,
University of Iowa
, Iowa City, IA 52242
Jia Lu
Department of Mechanical and Industrial Engineering,
University of Iowa
, Iowa City, IA 52242
Michael S. Sacks
Engineered Tissue Mechanics Laboratory, Department of Bioengineering,
University of Pittsburgh
, Pittsburgh, PA
Krishnan B. Chandran
Departments of Biomedical and Mechanical and Industrial Engineering,
University of Iowa
, Iowa City, IA IIHR-Hydroscience and Engineering, Iowa City, IA 52242e-mail: chandran@engineering.uiowa.edu
J Biomech Eng. Oct 2006, 128(5): 717-724 (8 pages)
Published Online: April 20, 2006
Article history
Received:
October 6, 2005
Revised:
April 20, 2006
Citation
Kim, H., Lu, J., Sacks, M. S., and Chandran, K. B. (April 20, 2006). "Dynamic Simulation Pericardial Bioprosthetic Heart Valve Function." ASME. J Biomech Eng. October 2006; 128(5): 717–724. https://doi.org/10.1115/1.2244578
Download citation file:
Get Email Alerts
Estimation of Joint Kinetics During Manual Material Handling Using Inertial Motion Capture: A Follow-Up Study
J Biomech Eng (February 2025)
Effect of Compressive Strain Rates on Viscoelasticity and Water Content in Intact Porcine Stomach Wall Tissues
J Biomech Eng (February 2025)
Eyelid Motion Tracking During Blinking Using High-Speed Imaging and Digital Image Correlation
J Biomech Eng (January 2025)
Related Articles
Simulated Bioprosthetic Heart Valve Deformation under Quasi-Static Loading
J Biomech Eng (November,2005)
A Theoretical Framework to Analyze Bend Testing of Soft Tissue
J Biomech Eng (February,2007)
Mechanical Characterization of Anisotropic Planar Biological Soft
Tissues Using Large Indentation: A Computational Feasibility
Study
J Biomech Eng (June,2006)
Coupled Macroscopic and Microscopic Scale Modeling of Fibrillar Tissues and Tissue Equivalents
J Biomech Eng (August,2001)
Related Proceedings Papers
Related Chapters
Conclusion
Ultrasonic Methods for Measurement of Small Motion and Deformation of Biological Tissues for Assessment of Viscoelasticity
Data Tabulations
Structural Shear Joints: Analyses, Properties and Design for Repeat Loading
Mathematical Background
Vibrations of Linear Piezostructures