This study uses a reconstructed vascular geometry to evaluate the thermal response of tissue during a three-dimensional radiofrequency (rf) tumor ablation. MRI images of a sectioned liver tissue containing arterial vessels are processed and converted into a finite-element mesh. A rf heat source in the form of a spherically symmetric Gaussian distribution, fit from a previously computed profile, is employed. Convective cooling within large blood vessels is treated using direct physical modeling of the heat and momentum transfer within the vessel. Calculations of temperature rise and thermal dose are performed for transient rf procedures in cases where the tumor is located at three different locations near the bifurcation point of a reconstructed artery. Results demonstrate a significant dependence of tissue temperature profile on the reconstructed vasculature and the tumor location. Heat convection through the arteries reduced the steady-state temperature rise, relative to the no-flow case, by up to 70% in the targeted volume. Blood flow also reduced the thermal dose value, which quantifies the extent of cell damage, from , for the no-flow condition, to for basal flow . Reduction of thermal dose below the threshold value of indicates ablation procedures that may inadequately elevate the temperature in some regions, thereby permitting possible tumor recursion. These variations are caused by vasculature tortuosity that are patient specific and can be captured only by the reconstruction of the realistic geometry.
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e-mail: rupak@banerjee@uc.edu
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June 2007
Technical Papers
Radio-Frequency Ablation in a Realistic Reconstructed Hepatic Tissue
Prasanna Hariharan,
Prasanna Hariharan
Graduate Student Mechanical Engineering Department,
University of Cincinnati
, 688 Rhodes Hall, P.O. Box 210072, Cincinnati, OH 45221-0072
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Isaac Chang,
Isaac Chang
Biomedical Engineer Division of Physics, Center for Devices and Radiological Health,
US Food and Drug Administration
, 10903 New Hampshire Avenue, Building 62, Silver Spring, MD 20993-0002
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Matthew R. Myers,
Matthew R. Myers
Research Physicist Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health,
US Food and Drug Administration
, 10903 New Hampshire Avenue, Building 62, Silver Spring, MD 20993-0002
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Rupak K. Banerjee
Rupak K. Banerjee
Associate Professor Mechanical Engineering Department, 688 Rhodes Hall,
e-mail: rupak@banerjee@uc.edu
University of Cincinnati
, PO Box 210072 Cincinnati, OH 45221-0072
Search for other works by this author on:
Prasanna Hariharan
Graduate Student Mechanical Engineering Department,
University of Cincinnati
, 688 Rhodes Hall, P.O. Box 210072, Cincinnati, OH 45221-0072
Isaac Chang
Biomedical Engineer Division of Physics, Center for Devices and Radiological Health,
US Food and Drug Administration
, 10903 New Hampshire Avenue, Building 62, Silver Spring, MD 20993-0002
Matthew R. Myers
Research Physicist Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health,
US Food and Drug Administration
, 10903 New Hampshire Avenue, Building 62, Silver Spring, MD 20993-0002
Rupak K. Banerjee
Associate Professor Mechanical Engineering Department, 688 Rhodes Hall,
University of Cincinnati
, PO Box 210072 Cincinnati, OH 45221-0072e-mail: rupak@banerjee@uc.edu
J Biomech Eng. Jun 2007, 129(3): 354-364 (11 pages)
Published Online: November 19, 2006
Article history
Received:
March 18, 2006
Revised:
November 19, 2006
Citation
Hariharan, P., Chang, I., Myers, M. R., and Banerjee, R. K. (November 19, 2006). "Radio-Frequency Ablation in a Realistic Reconstructed Hepatic Tissue." ASME. J Biomech Eng. June 2007; 129(3): 354–364. https://doi.org/10.1115/1.2720912
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