Computational fluid dynamics (CFD) has emerged as a useful tool for the prediction of airflow and particle transport within the human lung airway. Several published studies have demonstrated the use of Eulerian finite-volume CFD simulations coupled with Lagrangian particle tracking methods to determine local and regional particle deposition rates in small subsections of the bronchopulmonary tree. However, the simulation of particle transport and deposition in large-scale models encompassing more than a few generations is less common, due in part to the sheer size and complexity of the human lung airway. Highly resolved, fully coupled flowfield solution and particle tracking in the entire lung, for example, is currently an intractable problem and will remain so for the foreseeable future. This paper adopts a previously reported methodology for simulating large-scale regions of the lung airway (Walters, D. K., and Luke, W. H., 2010, “A Method for Three-Dimensional Navier–Stokes Simulations of Large-Scale Regions of the Human Lung Airway,” ASME J. Fluids Eng., 132(5), p. 051101), which was shown to produce results similar to fully resolved geometries using approximate, reduced geometry models. The methodology is extended here to particle transport and deposition simulations. Lagrangian particle tracking simulations are performed in combination with Eulerian simulations of the airflow in an idealized representation of the human lung airway tree. Results using the reduced models are compared with those using the fully resolved models for an eight-generation region of the conducting zone. The agreement between fully resolved and reduced geometry simulations indicates that the new method can provide an accurate alternative for large-scale CFD simulations while potentially reducing the computational cost of these simulations by several orders of magnitude.
Skip Nav Destination
e-mail: walters@me.msstate.edu
e-mail: whl30@msstate.edu
Article navigation
January 2011
Research Papers
Computational Fluid Dynamics Simulations of Particle Deposition in Large-Scale, Multigenerational Lung Models
D. Keith Walters,
D. Keith Walters
Department of Mechanical Engineering, CAVS SimCenter,
e-mail: walters@me.msstate.edu
Mississippi State University
, P.O. Box ME, Mississippi State, MS 39762
Search for other works by this author on:
William H. Luke
William H. Luke
Department of Mechanical Engineering, CAVS SimCenter,
e-mail: whl30@msstate.edu
Mississippi State University
, P.O. Box ME, Mississippi State, MS 39762
Search for other works by this author on:
D. Keith Walters
Department of Mechanical Engineering, CAVS SimCenter,
Mississippi State University
, P.O. Box ME, Mississippi State, MS 39762e-mail: walters@me.msstate.edu
William H. Luke
Department of Mechanical Engineering, CAVS SimCenter,
Mississippi State University
, P.O. Box ME, Mississippi State, MS 39762e-mail: whl30@msstate.edu
J Biomech Eng. Jan 2011, 133(1): 011003 (8 pages)
Published Online: December 22, 2010
Article history
Received:
July 13, 2010
Revised:
October 14, 2010
Posted:
November 2, 2010
Published:
December 22, 2010
Online:
December 22, 2010
Citation
Walters, D. K., and Luke, W. H. (December 22, 2010). "Computational Fluid Dynamics Simulations of Particle Deposition in Large-Scale, Multigenerational Lung Models." ASME. J Biomech Eng. January 2011; 133(1): 011003. https://doi.org/10.1115/1.4002936
Download citation file:
Get Email Alerts
Related Articles
A Method for Three-Dimensional Navier–Stokes Simulations of Large-Scale Regions of the Human Lung Airway
J. Fluids Eng (May,2010)
Structured Tree Impedance Outflow Boundary Conditions for 3D Lung Simulations
J Biomech Eng (August,2010)
Dynamics of Voluntary Cough Maneuvers: A Theoretical Model
J Biomech Eng (January,2009)
Design of Pressurized Metered Dose Inhalers Modeling of Internal Flow and Atomization
J. Med. Devices (June,2010)
Related Chapters
CFD Simulations of a Mixed-flow Pump Using Various Turbulence Models
Mixed-flow Pumps: Modeling, Simulation, and Measurements
Advances in Computational Modeling of Sound Propagation in the Lungs and Torso with Diagnostic Applications
Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling
Modeling Device Interaction with the Neonatal Lung
Medical Devices for Respiratory Dysfunction: Principles and Modeling of Continuous Positive Airway Pressure (CPAP)