Parkinson's disease (PD) is a neurodegenerative disorder characterized by increased response times leading to a variety of biomechanical symptoms, such as tremors, stooping, and gait instability. Although the deterioration in biomechanical control can intuitively be related to sluggish response times, how the delay leads to such biomechanical symptoms as tremor is not yet understood. Only recently has it been explained from the perspective of feedback control theory that delay beyond a threshold can be the cause of Parkinsonian tremor (Palanthandalam-Madapusi and Goyal, 2011, “Is Parkinsonian Tremor a Limit Cycle?” J. Mech. Med. Biol., 11(5), pp. 1017–1023). The present paper correlates several observations from this perspective to clinical facts and reinforces them with simple numerical and experimental examples. Thus, the present work provides a framework toward developing a deeper conceptual understanding of the mechanism behind PD symptoms. Furthermore, it lays a foundation for developing tools for diagnosis and progress tracking of the disease by identifying some key trends.
Skip Nav Destination
Article navigation
January 2017
Research-Article
Clinical Facts Along With a Feedback Control Perspective Suggest That Increased Response Time Might Be the Cause of Parkinsonian Rest Tremor
Vrutangkumar V. Shah,
Vrutangkumar V. Shah
SysIDEA Lab,
Mechanical Engineering,
Indian Institute of Technology Gandhinagar,
Gandhinagar 382355, India
e-mail: shah_vrutangkumar@iitgn.ac.in
Mechanical Engineering,
Indian Institute of Technology Gandhinagar,
Gandhinagar 382355, India
e-mail: shah_vrutangkumar@iitgn.ac.in
Search for other works by this author on:
Sachin Goyal,
Sachin Goyal
Assistant Professor
Department of Mechanical Engineering,
University of California,
Merced, CA 95343
e-mail: sachin.goyal@ucmerced.edu
Department of Mechanical Engineering,
University of California,
Merced, CA 95343
e-mail: sachin.goyal@ucmerced.edu
Search for other works by this author on:
Harish J. Palanthandalam-Madapusi
Harish J. Palanthandalam-Madapusi
Assistant Professor
SysIDEA Lab,
Mechanical Engineering,
Indian Institute of Technology Gandhinagar,
Gandhinagar 382355, India
e-mail: harish@iitgn.ac.in
SysIDEA Lab,
Mechanical Engineering,
Indian Institute of Technology Gandhinagar,
Gandhinagar 382355, India
e-mail: harish@iitgn.ac.in
Search for other works by this author on:
Vrutangkumar V. Shah
SysIDEA Lab,
Mechanical Engineering,
Indian Institute of Technology Gandhinagar,
Gandhinagar 382355, India
e-mail: shah_vrutangkumar@iitgn.ac.in
Mechanical Engineering,
Indian Institute of Technology Gandhinagar,
Gandhinagar 382355, India
e-mail: shah_vrutangkumar@iitgn.ac.in
Sachin Goyal
Assistant Professor
Department of Mechanical Engineering,
University of California,
Merced, CA 95343
e-mail: sachin.goyal@ucmerced.edu
Department of Mechanical Engineering,
University of California,
Merced, CA 95343
e-mail: sachin.goyal@ucmerced.edu
Harish J. Palanthandalam-Madapusi
Assistant Professor
SysIDEA Lab,
Mechanical Engineering,
Indian Institute of Technology Gandhinagar,
Gandhinagar 382355, India
e-mail: harish@iitgn.ac.in
SysIDEA Lab,
Mechanical Engineering,
Indian Institute of Technology Gandhinagar,
Gandhinagar 382355, India
e-mail: harish@iitgn.ac.in
1Corresponding author.
Contributed by the Design Engineering Division of ASME for publication in the JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS. Manuscript received November 25, 2015; final manuscript received June 24, 2016; published online September 1, 2016. Assoc. Editor: Sotirios Natsiavas.
J. Comput. Nonlinear Dynam. Jan 2017, 12(1): 011007 (8 pages)
Published Online: September 1, 2016
Article history
Received:
November 25, 2015
Revised:
June 24, 2016
Citation
Shah, V. V., Goyal, S., and Palanthandalam-Madapusi, H. J. (September 1, 2016). "Clinical Facts Along With a Feedback Control Perspective Suggest That Increased Response Time Might Be the Cause of Parkinsonian Rest Tremor." ASME. J. Comput. Nonlinear Dynam. January 2017; 12(1): 011007. https://doi.org/10.1115/1.4034050
Download citation file:
Get Email Alerts
Cited By
Investigation of Nonlinear Dynamic Behaviors of Vertical Rotor System Supported by Aerostatic Bearings
J. Comput. Nonlinear Dynam (January 2025)
Electric Circuit Analogs of First-Order Dual-Phase-Lag Diffusion
J. Comput. Nonlinear Dynam
Related Articles
Oscillation Control of Quay-Side Container Cranes Using Cable-Length Manipulation
J. Dyn. Sys., Meas., Control (March,2007)
Sensitivity Enhancement of Cantilever-Based Sensors Using Feedback Delays
J. Comput. Nonlinear Dynam (October,2010)
Robust Generation of Limit Cycles in Nonlinear Systems: Application on Two Mechanical Systems
J. Comput. Nonlinear Dynam (July,2017)
Related Proceedings Papers
Related Chapters
Pre-Accidental Situations Highlighted by RECUPERARE Method and Data (PSAM-0029)
Proceedings of the Eighth International Conference on Probabilistic Safety Assessment & Management (PSAM)
A Design Method for Modified Smith Predictors for Non-Minimum-Phase Time-Delay Plants with Feedback Connected Multiple Time-Delays
Intelligent Engineering Systems through Artificial Neural Networks Volume 18
A New Mobile Haptic Game for Dynamic Objects
International Conference on Software Technology and Engineering (ICSTE 2012)