This special issue contains a selection of 14 manuscripts (two technical briefs and 12 research papers) from the 43nd American Society of Mechanical Engineers (ASME) Computers and Information in Engineering (CIE) Conference that was held in Boston, MA, August 20–23, 2023, in conjunction with the International Design Engineering Technical Conferences (IDETCs). Nominated by the four technical committees, namely, Advanced Modeling and Simulation (AMS), Computer Aided Product and Process Development (CAPPD), Systems Engineering, Information and Knowledge Management (SEIKM), and Virtual Environments and Systems (VES) based on the conference paper review results, these papers reflect recent and relevant advancements in these technical areas.