Abstract
Metabolic profiles of 11-nor-9-carboxylic acid-Δ9-tetrahydrocannabinol (COOH-THC) and other THC metabolites were determined in an infrequent and a frequent marijuana user by high performance liquid chromatography-radioimmunoassay (HPLC-RIA). In the infrequent user, no unconjugated COOH-THC was detected in urine samples for the first 8 h following smoking, whereas this metabolite was detected in the urine samples from a frequent user. A metabolite was also detected in the frequent user, which was not present in the urine sample from the infrequent user.
Issue Section:
Technical Notes
References
1.
Williams
, P. L.
and Moffat
, A. C.
, “Identification in Human Urine of Δ9-Tetrahydrocannabinol-11-oic Acid Glucuronide: A Tetrahydrocannabinol Metabolite
,” Journal of Pharmacy and Pharmacology
0373-1022, Vol. 31
, 1980
, pp. 445
-448
.2.
Pallante
, S.
, Lyle
, M. A.
, and Fenselau
, C.
, “Synthesis and Characterization of Glucuronides of 5′-Hydroxy-Delta-9-THC and 11-Hydroxy-Delta-9-THC
,” Drug Metabolism and Disposition
0090-9556, Vol. 6
, 1978
, pp. 389
-395
.3.
Peat
, M. A.
, McGinnis
, K. M.
, Johnson
, J. R.
, Galinsky
, R. E.
, Foltz
, R. L.
, and Jones
, R. T.
, “The Disposition of Δ9-Tetrahydrocannabinol, 11-Hydroxy-Δ9-Tetrahydrocannabinol and 11-Nor-9-Carboxylic Acid-Δ9-Tetrahydrocannabinol in Frequent and Infrequent Marijuana Users
,” Journal of Pharmacology and Experimental Therapeutics
0022-3565.4.
Law
, B.
, Mason
, P. A.
, Moffat
, A. C.
, Gleadle
, R. I.
, and King
, L. J.
, “Forensic Aspects of the Metabolism and Excretion of Cannabinoids following Oral Ingestion of Cannabis Resin
,” Journal of Pharmacology and Pharmacology
, Vol. 36
, 1983
, pp. 289
-294
.5.
Peat
, M. A.
, “The Analysis of Δ9-Tetrahydrocannabinol and its Metabolites by Immunoassay
,” in Advances in Analytical Toxicology
, Vol. 1
, R. C.
Baselt
, Ed., Biomedical Publications
, Foster City, CA
, 1984
, pp. 59
-80
.6.
Kanter
, S. L.
, Hollister
, L. E.
, and Zamora
, J. U.
, “Marijuana Metabolites in Urine of Man XI. Detection of Unconjugated and Conjugated Δ9-Tetrahydrocannabinol-11-oic Acid by Thin Layer Chromatography
,” Journal of Chromatography
0021-9673, Vol. 235
, 1982
, pp. 507
-512
.7.
Whiting
, J. D.
and Mandrs
, W. W.
, “Confirmation of a Tetrahydrocannabinol Metabolite in Urine by Gas Chromatography
,” Journal of Analytical Toxicology
0146-4760, Vol. 6
, 1982
, pp. 49
-52
.8.
El Sohly
, M. A.
, Arafat
, E. S.
, and Jones
, A. B.
, “Analysis of the Major Metabolite Δ9-Tetrahydrocannabinol in Urine. III. A GC/ECD Procedure
,” Journal of Analytical Toxicology
0146-4760, Vol. 8
, 1984
, pp. 7
-9
.9.
Foltz
, R. L.
, “Analysis of Cannabinoids in Physiological Specimens by Gas Chromatography/Mass Spectrometry
,” in Advances in Analytical Toxicology
, Vol. 1
, R. C.
Baselt
, Ed., Biomedical Publications
, Foster City, CA
, 1984
, pp. 125
-157
.10.
El Sohly
, M. A.
, El Sohly
, H. N.
, Jones
, A. B.
, Dimson
, P. A.
, and Wells
, K. E.
, “Analysis of the Major Metabolite of Δ9-Tetrahydrocannabinol in Urine. II. A HPLC Procedure
,” Journal of Analytical Toxicology
0146-4760, Vol. 7
, 1983
, pp. 262
-264
.11.
Posey
, B. L.
and Kimble
, S. N.
, “Quantitative Determination of 11-Nor-Δ9-Tetrahydrocannabinol and its Metabolites in Urine by HPLC
,” Journal of Analytical Toxicology
0146-4760, Vol. 8
, 1984
, pp. 234
-238
.12.
Peat
, M. A.
, Deyman
, M. E.
, and Johnson
, J. R.
, “High Performance Liquid Chromatography-Immunoassay of Δ9-Tetrahydrocannabinol and Its Metabolites in Urine
,” Journal of Forensic Sciences
0022-1198, Vol. 29
, No. 1
, 01
1984
, pp. 110
-119
.13.
Law
, B.
, Mason
, P. A.
, Moffat
, A. C.
, and King
, L. J.
, “Confirmation of Cannabis Use by the Analysis of Δ9-Tetrahydrocannabinol Metabolites in Blood and Urine by Combined HPLC and RIA
,” Journal of Analytical Toxicology
0146-4760, Vol. 8
, 1984
, pp. 19
-22
.14.
Halldin
, M. M.
, Widman
, M.
, Agurell
, S.
, Hollister
, L. E.
, and Kanter
, S. L.
, “Acidic Metabolites of Delta-1-Tetrahydrocannabinol Excreted in the Urine of Man
,” in The Cannabinoids: Chemical, Pharmacologic, and Therapeutic Aspects
, S.
Agurell
, W. L.
Dewey
, and R. E.
Willette
, Eds., Academic Press
, New York
, 1984
, pp. 221
-218
.
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