...AG Del Signore; M McGregor, Ph.D.; BP Cho, Ph.D. A 1 H nuclear magnetic resonance ( 1 H NMR) method for the determination of gamma-hydroxybutyric acid (GHB) and gamma-hydroxybutyrolactone (GBL) in human serum and urine using spiked samples has been developed. The method gives linear responses...

...L Sreerama, PhD; GG Hardin, MPH Evidentiary urine samples (n = 345) stored frozen at -20°C in their original containers (leakproof 100 mL plastic bottles) upon retesting for ethanol resulted in concentrations that were significantly lower (average loss = ~30%) than those prior to their storage...

...T Yasuda, PhD; R Iida, PhD; H Takeshita, MD; M Ueki, BS; T Nakajima, PhD; Y Kaneko, MD; K Mogi, MD; T Tsukahara, BS; K Kishi, MD PhD We devised a simple DNA extraction procedure suitable for STR typing of urine sample. Use of a commercially available DNA/RNA extraction kit equipped with a silica...

...G Ceder, B.S.; AW Jones, D.Sc. Concentrations of unconjugated morphine, codeine and 6-acetylmorphine (6-AM), the specific metabolite of heroin, were determined in urine specimens from 339 individuals apprehended for driving under the influence of drugs (DUID) in Sweden. After an initial screening...

...D Felscher, Ph.D.; K Schulz, Ph.D. This study describes screening and identifying amphetamines, methamphetamines, and their derivatives in urine using immunochemical (Triage™ 8 , FPIA) and chromatographic techniques (REMEDi™ HS). Amphetamines, methamphetamines, MDMA (3,4...

...SA Lewis, Sr, M.S.; LA Lewis, Ph.D.; A Tuinman, Ph.D. Recently potassium nitrite has been used as an adulterant to interfere with the analysis of 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in urine. A comprehensive study of the THC-COOH and nitrite reaction chemistry...

...SA White, B.Sc.; AS Kidd, M.Sc.; KS Webb, Ph.D. The use of isotope dilution mass spectrometry (IDMS) has been investigated for the forensic confirmation of lysergic acid diethylamide (LSD) in urine by LC-MS. The advantages of using a deuterated analog of LSD as an internal standard over...

...DR Linfert, B.A.; AHB Wu, Ph.D.; GJ Tsongalis, Ph.D. Human urine has not been adequately investigated as a potential source of DNA for forensic identity testing. The advent of polymerase chain reaction technology has made possible the analysis of previously undetectable levels of nucleic acids from...

... of toxicological urine analysis from drivers suspected of driving under the influence of drugs in Vienna from 1993 to 1996 were investigated. Decisive for police intervention was “unsafe driving” (swerving, hesitating, going too slowly, etc.), driving at high speed within the city limits, driving through red...

... was intended to determine the prevalence of opiates, cocaine metabolites, cannabinoids and amphetamines in the urine of drivers injured in road accidents and to compare these values with those of non-accident subjects (“patients”) in France. Recruitment was performed nationwide in the emergency departments...

...J de Kanel, M.Sc.; WE Vickery; B Waldner, AS; RM Monahan; FX Diamond, B.Sc. A forensic procedure for the quantitative confirmation of lysergic acid diethylamide (LSD) and the qualitative confirmation of its metabolite, N-demethyl-LSD, in blood, serum, plasma, and urine samples is presented...

...D Felscher, Ph.D.; G Gastmeier, Ph.D.; J Dressler, M.D. The investigations presented are aimed at testing whether ABBOTT's fluorescence polarization immunoassays for identification of drugs of abuse and pharmaceuticals in serum and urine are applicable to knee joint synovial fluid and vitreous...

...KS Webb, Ph.D.; PB Baker, Ph.D.; NP Cassells, M.Sc.; JM Francis, Ph.D.; DE Johnston, M.Sc.; SL Lancaster, M.Sc.; PS Minty, B.Sc.; GD Reed, B.Sc.; SA White, B.Sc. A forensic procedure for the screening and confirmation of the presence of lysergide (lysergic acid diethylamide, LSD) in urine...

...GJ Tsongalis, Ph.D.; DE Anamani, B.Sc.; AHB Wu, Ph.D. We evaluated the ability to genotype DNA extracted from urine samples, which were previously submitted for toxicological analysis, by either the AmpliType HLA DQα or the combined PM+DQA1 amplification and typing systems. Initial experiments were...

...IS DuBey, M.S.; YH Caplan, Ph.D. The feasibility of storing forensic urine drug specimens as dry stains on Whatman #3 paper was studied by evaluating the stability of the drugs and recovery from the stains. Drug stains prepared from urine (3 mL) were stored at − 20°C, 4°C, and at room temperature...

...BK Logan, Ph.D. DABFT; EW Schwilke Blood and/or urine from fatally injured drivers in Washington State were collected and tested for the presence of drugs and alcohol. Drug and/or alcohol use was a factor in 52% of all fatalities. Among single vehicle accidents, alcohol use was a factor in 61...

...B Levine, Ph.D.; V Ramcharitar, M.S.; JE Smialek, M.D. In this study, 25 postmortem urine specimens testing positive, for cocaine and ecogonine methyl ester (EME) by full scan electron impact gas chromatography/mass spectrometry, were used to evaluate the stability of EME in refrigerated and frozen...

...L Debrabandere, Ph.D.; M Van Boven, D.Sc.; P Daenens, D.Sc. The development of a fluoroimmunoassay for the detection of buprenorphine in urine samples is described. Fluore-scein-norbuprenorphine and pseudobuprenorphine, the dimer of buprenorphine, were synthesized as tracer molecules...

...A Helander, Ph.D.; O Beck, Ph.D.; AW Jones, Ph.D., D.Sc. During the metabolism of ethanol, the metabolic conversion of serotonin (5-hydroxytryptamine) is altered, and, as a consequence, the ratio of 5-hydroxytryptophol (5HTOL) to 5-hydroxyindole-3-acetic acid (5HIAA) excreted in urine increases...

... to gas chromatographic screening. To ascertain the merits of screening BE versus EME for identifying cocaine use, 380 consecutive urine specimens presented to the Office of the Chief Medical Examiner-State of Maryland were tested for BE by EMIT (cutoff 0.3 mg/L) and for EME by gas chromatography-nitrogen...