Patients treated by current ventricular assist devices (VADs) suffer from various post implantation complications including gastrointestinal bleeding and arteriovenous malformation. These issues are related to intrinsically mismatch of generated flow by VADs and the physiological flow. In addition, the common primary drawback of available VADs is excessive surgical dissection during implantation, which limits these devices to less morbid patients. We investigated an alternative soft VAD (SVAD) system that generates physiological flow, and designed to be implanted using minimally invasive surgery by leveraging soft materials. A soft VAD (which is an application of intraventricular balloon pump) is developed by utilizing a polyurethane balloon, which generates pulsatile flow by displacing volume within the left ventricle during its inflation and deflation phases. Our results show that the SVAD system generates an average ejection fraction of 50.18 ± 1.52% (n = 6 ± SD) in explanted porcine hearts. Since the SVAD is implanted via the apex of the heart, only a minithoracotomy should be required for implantation. Our results suggest that the SVAD system has the performance characteristics that could potentially make it useful for patients in acute and/or chronic heart failure, thus serving as a bridge-to-transplantation or bridge-to-recovery.
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June 2019
Research-Article
A Proof-of-Concept Demonstration for a Novel Soft Ventricular Assist Device
Saleh H. Gharaie,
Saleh H. Gharaie
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: s.gharaie@deakin.edu.au
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: s.gharaie@deakin.edu.au
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Amir Ali Amir Moghadam,
Amir Ali Amir Moghadam
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: ama2041@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: ama2041@med.cornell.edu
Search for other works by this author on:
Subhi J. Al'Aref,
Subhi J. Al'Aref
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sua9028@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sua9028@med.cornell.edu
Search for other works by this author on:
Alexandre Caprio,
Alexandre Caprio
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: alex.caprio1@gmail.com
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: alex.caprio1@gmail.com
Search for other works by this author on:
Seyedhamidreza Alaie,
Seyedhamidreza Alaie
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sea2012@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sea2012@med.cornell.edu
Search for other works by this author on:
Mohamed Zgaren,
Mohamed Zgaren
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: zgaren@gmail.com
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: zgaren@gmail.com
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James K. Min,
James K. Min
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: jkm2001@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: jkm2001@med.cornell.edu
Search for other works by this author on:
Simon Dunham,
Simon Dunham
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sid2012@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sid2012@med.cornell.edu
Search for other works by this author on:
Bobak Mosadegh
Bobak Mosadegh
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: bom2008@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: bom2008@med.cornell.edu
1Corresponding author.
Search for other works by this author on:
Saleh H. Gharaie
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: s.gharaie@deakin.edu.au
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: s.gharaie@deakin.edu.au
Amir Ali Amir Moghadam
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: ama2041@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: ama2041@med.cornell.edu
Subhi J. Al'Aref
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sua9028@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sua9028@med.cornell.edu
Alexandre Caprio
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: alex.caprio1@gmail.com
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: alex.caprio1@gmail.com
Seyedhamidreza Alaie
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sea2012@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sea2012@med.cornell.edu
Mohamed Zgaren
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: zgaren@gmail.com
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: zgaren@gmail.com
James K. Min
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: jkm2001@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: jkm2001@med.cornell.edu
Simon Dunham
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sid2012@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: sid2012@med.cornell.edu
Bobak Mosadegh
Dalio Institute of Cardiovascular Imaging,
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: bom2008@med.cornell.edu
Department of Radiology,
New York-Presbyterian Hospital and
Weill Cornell Medicine,
413 E.69th street, Suite 108,
New York, NY 10021
e-mail: bom2008@med.cornell.edu
1Corresponding author.
Manuscript received July 31, 2018; final manuscript received January 21, 2019; published online April 16, 2019. Assoc. Editor: Prasanna Hariharan.
J. Med. Devices. Jun 2019, 13(2): 021009 (10 pages)
Published Online: April 16, 2019
Article history
Received:
July 31, 2018
Revised:
January 21, 2019
Citation
Gharaie, S. H., Amir Moghadam, A. A., Al'Aref, S. J., Caprio, A., Alaie, S., Zgaren, M., Min, J. K., Dunham, S., and Mosadegh, B. (April 16, 2019). "A Proof-of-Concept Demonstration for a Novel Soft Ventricular Assist Device." ASME. J. Med. Devices. June 2019; 13(2): 021009. https://doi.org/10.1115/1.4043052
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