A portable transcranial magnetic stimulation (TMS) prototype was designed and constructed for use in clinical trials to manage the pain associated with migraine with aura. In this system, a half-sinusoid (optionally a full-sine) TMS pulse is delivered into a circular coil. The pulse triggering is controlled by a switch in the coil handle. The pulse intensity and polarity are adjustable. Measured pulse parameters (period , maximum magnetic field at coil center ) corresponded to expected values and were in the range described for commercially available TMS apparatus. The maximum current density, computed 3 cm below the coil using a simple model of brain anatomy, was approximately 1.9 times the motor threshold, thus ensuring a sufficient margin for reaching the neuronal threshold in the target area.
1.
Lane
, R.
, and Davies
, P.
, 2006, Migraine
, Taylor & Francis
, London
.2.
Fumal
, A.
, Bohotin
, V.
, Vandenheede
, M.
, and Schoenen
, J.
, 2003, “Transcranial Magnetic Stimulation in Migraine: A Review of Facts and Controversies
,” Acta Neurol. Belg.
0300-9009, 103
, pp. 144
–154
.3.
Brighina
, F.
, Piazza
, A.
, Daniele
, O.
, and Fierro
, B.
, 2002, “Modulation of Visual Cortical Excitability in Migraine With Aura: Effects of 1 Hz Repetitive Transcranial Magnetic Stimulation
,” Exp. Brain Res.
0014-4819, 145
, pp. 177
–181
.4.
Brighina
, F.
, Giglia
, G.
, Scalia
, S.
, Francolini
, M.
, Palermo
, A.
, and Fierro
, B.
, 2005, “Facilitatory Effects of 1 Hz rTMS in Motor Cortex of Patients Affected by Migraine With Aura
,” Exp. Brain Res.
0014-4819, 161
, pp. 34
–38
.5.
Bolay
, H.
, Reuter
, U.
, Dunn
, A. K.
, Huang
, Z.
, Boas
, D. A.
, and Moskowitz
, M. A.
, 2002, “Intrinsic Brain Activity Triggers Trigeminal Meningeal Afferents in a Migraine Model
,” Nat. Med.
1078-8956, 8
, pp. 136
–142
.6.
Fumal
, A.
, Coppola
, G.
, Bohotin
, V.
, Gérardy
, P. -Y.
, Seidel
, L.
, Donneau
, A. -F.
, Vandenheede
, M.
, Maertens de Noordhout
, A.
, and Schoenen
, J.
, 2006, “Induction of Long-Lasting Changes of Visual Cortex Excitability by Five Daily Sessions of Repetitive Transcranial Magnetic Stimulation (rTMS) in Healthy Volunteers and Migraine Patients
,” Cephalalgia
0333-1024, 26
, pp. 143
–149
.7.
Boroojerdi
, B.
, Prager
, A.
, Muellbacher
, W.
, and Cohen
, L. G.
, 2000, “Reduction of Human Visual Cortex Excitability Using 1-Hz Transcranial Magnetic Stimulation
,” Neurology
0028-3878, 54
, pp. 1529
–1531
.8.
Marangell
, L. B.
, Martinez
, M.
, Jurdi
, R. A.
, and Zboyan
, H.
, 2007, “Neurostimulation Therapies in Depression: A Review of New Modalities
,” Acta Psychiatr. Scand.
0001-690X, 116
, pp. 174
–181
.9.
Mohammad
, Y. M.
, Hughes
, G.
, Nkrumah
, M.
, Fischell
, S.
, Fischell
, R.
, Ruppel
, P.
, and Schweiger
, J.
, 2006, “Self-Administered Transcranial Magnetic Stimulation (TMS), During the Aura Phase, Improves and Aborts Migraine Headache
,” Presented at the 48th Annual Meeting of the American Headache Society
, Los Angeles, CA, Jun. 22–25.10.
Clarke
, B. M.
, Upton
, A. R. M.
, Kamath
, M. V.
, Al-Harbi
, T.
, and Castellanos
, C. M.
, 2006, “Transcranial Magnetic Stimulation for Migraine: Clinical Effects
,” J. Headache and Pain
, 7
, pp. 341
–346
.11.
Charlet de Sauvage
, R.
, Grattepanche
, F.
, Cassand
, P.
, Caubet
, R.
, and Moreau
, J. M.
, 2003, “Safety of the Magnetic Field Generated by a Neuronal Magnetic Stimulator: Evaluation of Possible Mutagenic Effects
,” Clin. Neurophysiol.
1388-2457, 114
, pp. 581
–588
.12.
Charlet de Sauvage
, R.
, Lagroye
, I.
, Billaudel
, B.
, and Veyret
, B.
, 2008, “Evaluation of the Potential Genotoxic Effects of rTMS on the Rat Brain and Current Density Mapping
,” Clin. Neurophysiol.
1388-2457, 119
, pp. 482
–491
.13.
Grattepanche
, F.
, Bourven
, I.
, Moreau
, J. M.
, Caubet
, R.
, le Marrec
, C.
, and Charlet de Sauvage
, R.
, 2004, “Pulsed Magnetic Field Treatment Modifies Corynephage ϕAAU2 Propagation on ‘Arthrobacter Aureus’
,” CEF9-International Congress on Engineering and Food
, Montpellier (Le Corum), Mar. 7–11, Vol. 546
, p. 4
.14.
Madec
, F.
, Billaudel
, B.
, Charlet de Sauvage
, R.
, Sartor
, P.
, and Veyret
, B.
, 2003, “Effects of ELF and Static Magnetic Fields on Calcium Oscillations in Islets of Langerhans
,” Bioelectrochemistry
1567-5394, 60
, pp. 73
–80
.15.
Jalinous
, R.
, 2003, Guide to Magnetic Stimulation
, Magstim Co. Ltd.
, Carmarthenshire, Wales, U.K.
16.
Bohotin
, V.
, Fumal
, A.
, Vandenheede
, M.
, Gérard
, P.
, Bohotin
, C.
, Maertens de Noordhout
, A.
, and Schoenen
, J.
, 2002, “Effects of Repetitive Transcranial Magnetic Stimulation on Visual Evoked Potentials in Migraine
,” Brain
0006-8950, 125
, pp. 912
–922
.17.
Stoy
, R. D.
, Foster
, K. R.
, and Schwan
, H. P.
, 1982, “Dielectric Properties of Mammalian Tissues From 0.1 to 100 MHz: A Summary of Recent Data
,” Phys. Med. Biol.
0031-9155, 27
, pp. 501
–513
.18.
Stein
, R. B.
, 1967, “The Frequency of Nerve Action Potentials Generated by Applied Currents
,” Proc. R. Soc. London, Ser. B
0962-8452, 167
, pp. 64
–86
.19.
Tamas
, A. A.
, Kincses
, Z.
, Nitsche
, M. A.
, Bartfai
, O.
, Demmer
, I.
, Sommer
, M.
, and Paulus
, W.
, 2003, “Pulse Configuration-Dependent Effects of Repetitive Transcranial Magnetic Stimulation on Visual Perception
,” NeuroReport
0959-4965, 13
, pp. 2229
–2233
.20.
Sommer
, M.
, Alfaro
, A.
, Rummel
, M.
, Speck
, S.
, Lang
, N.
, Tings
, T.
, and Paulus
, W.
, 2006, “Half Sine, Monophasic and Biphasic Transcranial Magnetic Stimulation of the Human Motor Cortex
,” Clin. Neurophysiol.
1388-2457, 117
, pp. 838
–844
.21.
Kammer
, T.
, Beck
, S.
, Erb
, M.
, and Grodd
, W.
, 2001, “The Influence of Current Direction on Phosphene Thresholds Evoked by Transcranial Magnetic Stimulation
,” Clin. Neurophysiol.
1388-2457, 112
, pp. 2015
–2021
.22.
Pascual-Leone
, A.
, Bartres-Faz
, D.
, and Keenan
, J. P.
, 1999, “Transcranial Magnetic Stimulation: Studying the Brain-Behaviour Relationship by Induction of “Virtual Lesions”
,” Philos. Trans. R. Soc. London, Ser. B
0962-8436, 354
, pp. 1229
–1238
.23.
Robertson
, E. M.
, Theoret
, H.
, and Pascual-Leone
, A.
, 2003, “Studies in Cognition: The Problems Solved and Created by Transcranial Magnetic Stimulation
,” J. Cogn. Neurosci.
0898-929X, 15
, pp. 948
–960
.24.
Schieber
, M. H.
, 2001, “Constraints on Somatotopic Organization in the Primary Motor Cortex
,” J. Neurophysiol.
0022-3077, 86
, pp. 2125
–2143
.25.
Penfield
, W.
, and Rasmussen
, T.
, 1950, The Cerebral Cortex of Man
, Macmillan
, New York
.26.
Hori
, H.
, Moretti
, G.
, Rebora
, A.
, and Crovato
, F.
, 1972, “The Thickness of Human Scalp: Normal and Bald
,” J. Invest. Dermatol.
0022-202X, 58
, pp. 396
–399
.27.
Lynnerup
, N.
, 2001, “Cranial Thickness in Relation to Age, Sex and General Body Build in a Danish Forensic Sample
,” Forensic Sci. Int.
0379-0738, 117
, pp. 45
–51
.28.
Butman
, J. A.
and Floeter
, M. K.
, 2007, “Decreased Thickness of Primary Motor Cortex in Primary Lateral Sclerosis
,” AJNR Am. J. Neuroradiol.
0195-6108, 28
, pp. 87
–91
.29.
Bailleul
, J. L.
, Guyonvarchb
, G.
, Garniera
, B.
, Jarnya
, Y.
, and Delaunay
, D.
, 1996, “Identification of Glass Fiber/Thermosetting Resins Composites Thermal Properties: Application to the Optimization of Molding Processes
,” Rev. Gen. Therm.
0035-3159, 35
, pp. 65
–76
.30.
Elwassif
, M. M.
, Kong
, Q.
, Vazquez
, M.
, and Bikson
, M.
, 2006, “Biol.-Heat Transfer Model of Deep Brain Stimulation-Induced Temperature Changes
,” J. Neural Eng.
1741-2560, 3
, pp. 306
–315
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