Two commercially available stents (the Palmaz–Schatz (PS) and S670 stents) with reported high and low restenosis rates, respectively, have been investigated in this paper. Finite element models simulating the stent, plaque, and artery interactions in 3 mm stenosed right coronary arteries were developed. These models were used to determine the stress field in artery walls after stent implantation. The material properties of porcine arteries were measured and implemented in the numerical models. The stress concentration induced in the artery by the PS stent was found to be more than double that of the S670 stent. It demonstrated a good correlation with the reported restenosis rate. The effects of stent structures, compliance mismatch, plaque geometry, and level of stenosis were studied. Results suggested that stent designs and tissue properties cause alterations in vascular anatomy that adversely affect arterial stress distributions within the wall, which impact vessel responses such as restenosis. Appropriate modeling of stent, plaque, and artery interactions provided insights for evaluating alterations to the arterial mechanical environment, as well as biomechanical factors leading to restenosis.
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September 2010
Research Papers
The Relation Between the Arterial Stress and Restenosis Rate After Coronary Stenting
Linxia Gu,
Linxia Gu
Department of Mechanical Engineering,
e-mail: lgu2@unl.edu
University of Nebraska-Lincoln
, Lincoln, NE 68588-0656
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Shijia Zhao,
Shijia Zhao
Department of Mechanical Engineering,
University of Nebraska-Lincoln
, Lincoln, NE 68588-0656
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Aswini K. Muttyam,
Aswini K. Muttyam
C-Lock Technology Inc.
, Rapid City, SD 57701
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James M. Hammel
James M. Hammel
Department of Surgery,
University of Nebraska Medical Center
, Omaha, NE 68114
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Linxia Gu
Department of Mechanical Engineering,
University of Nebraska-Lincoln
, Lincoln, NE 68588-0656e-mail: lgu2@unl.edu
Shijia Zhao
Department of Mechanical Engineering,
University of Nebraska-Lincoln
, Lincoln, NE 68588-0656
Aswini K. Muttyam
C-Lock Technology Inc.
, Rapid City, SD 57701
James M. Hammel
Department of Surgery,
University of Nebraska Medical Center
, Omaha, NE 68114J. Med. Devices. Sep 2010, 4(3): 031005 (7 pages)
Published Online: August 31, 2010
Article history
Received:
May 19, 2010
Revised:
July 16, 2010
Online:
August 31, 2010
Published:
August 31, 2010
Citation
Gu, L., Zhao, S., Muttyam, A. K., and Hammel, J. M. (August 31, 2010). "The Relation Between the Arterial Stress and Restenosis Rate After Coronary Stenting." ASME. J. Med. Devices. September 2010; 4(3): 031005. https://doi.org/10.1115/1.4002238
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