... concentrations of a low-molecular weight drug in the human lumbar disk. A quasi-static experiment and a dynamic computer finite element simulation were used to study the spread of lidocaine in the lumbar disk. Fresh-frozen cadaveric lumbar motion segments were immersed in a 0.1% lidocaine HCl solution for 6 days...

... spatially for tissue engineering and drug release. Imaging techniques are applied to explore distribution of microspheres over porous structures. Using microspheres in this study represents a framework for modeling the distribution characteristics of encapsulated proteins, growth factors, cells, and drugs...

...Oleg Vesnovsky; Jon P. Casamento; Mary E. Brooks; Matthew R. Schwerin; William A. Herman; Steven K. Pollack; Marilyn N. Flack; Betty W. Collins; Laurence W. Grossman The Food and Drug Administration received complaints of Huber needles creating cores in the septa of ports of gastric banding devices...

... Sciences, Inc. biomedical MRI biomedical ultrasonics cancer cryogenics drugs freezing surgery tumours 09 07 2009 2009 American Society of Mechanical Engineers ...

...A. Garg; A. W. Tisdale; E. Kokkoli The ability to target cancer cells using an appropriate drug delivery system can significantly reduce the associated side effects from cancer therapies and can help in improving overall quality of life post cancer survival. Integrin α 5 β 1 is expressed on several...

...E. S. Richardson; B. A. Whitson, MD; P. A. Iaizzo Atrial fibrillation (AF) is a common heart rhythm disorder, effecting about 20% of cardiac surgical patients. While often benign, it leads to a prolonged hospital stay, and potentially to malignant arrhythimas. Many anti-arrhythmic drugs have been...

... by ectopic beats originating in the myocardial sleeves surrounding the pulmonary viens. Pulmonary vein (PV) isolation via radio frequency ablation is the current gold standard for treating patients with drug-refractory AF. However, cryoablation is emerging as a new minimally-invasive technique to achieve PV...

... and postlaunch assessment. The study results suggest that stage-gate processes are the predominant development model used in the medical device industry and that regulatory requirements such as the food and drug adminstration (FDA’s) Quality Systems Regulation play a substantive role in shaping activities...

...Matthew Pausley; Stefan Seelecke Drug delivery via inhalation of drug aerosols has long been a standard procedure for the treatment of respiratory ailments. A number of researchers have explored the use of inhaled drugs as a novel way to administer new, often aggressive, drugs. However...

... of levofloxacin and they encourage the selection of resistant mutants from biofilm. Discussion: Implanted medical devices are quite common and are subjected to biofilm infections. Increasing multi-drug resistance underscores the need to conserve current antibiotics by judicious use. This necessitates...

... ferromagnetic behavior, less sensitivity to oxidation and relatively low toxicity compared to many other magnetic materials (e.g., iron, nickel and cobalt). 25 06 2008 biomedical MRI cancer drugs magnetic fluids nanoparticles nanotechnology patient diagnosis pH measurement tumours...

...Bruce Lindner; Michael Curtis; Jonas Weissenrieder; Mark Schwab Moisture levels in medical device packages influence a variety of crucial device properties, e.g. mechanical properties, corrosion and leach rates, drug potency, and ultimately shelf life. This is especially true for drug releasing...

...Thomas C. Bischoff; Marty D. Martens; Matthew H. Adams; William J. Gallagher; Paul A. Iaizzo Anecdotal and documented reports from both patients and doctors have described unanticipated breaks in connections between implanted catheters and drug pumps. In extreme cases, such disconnections...

... drug-eluting stents to locally deliver immunosuppressant and antiproliferative drugs. In this project, Fick’s law of diffusion was used to model drug diffusion from the stent matrix into the adjacent arterial tissue. An analytical procedure was also developed to estimate the circumferential...